Mecobalamin VB12

Quick Details

• Cas No： 13422-55-4
• Appearance： powder
• Delivery Time： 3-5days after ordering
• Packing： 1kg/bag, 25kg/drum
• Throughput： 1ton/week
• Purity： 0.98

CAS:

13422-55-4

MF:

C63H90CoN13O14P

MW:

1343.4

EINECS:

236-535-3

Properties

Melting point:

>190°C (dec.)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

pka

pK1:7.64(+1) (25°C)

Water Solubility 

Partially soluble in cold water, hot water.

 

Uses	1.It is used for the treatment of nervous system diseases, relieving pain and numbness, speeded relieving pain, improving pain caused by cervical spondylosis, treatment of sudden deafness, etc. 2.Methylcobalamin is a kind of endogenous coenzyme B12, participating in the one carbon unit cycle, playing an important role in the synthesis of methionine homocysteine methyl transfer reaction process.
Description	Methylcobalamin is an analog of vitamin B12 (Item No. 18425) with diverse neurological activities. It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 μM. Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine (Item No. 11764) in a rat model of neuropathic pain. Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS). It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.
Chemical Properties	Dark Red Crystalline Powder